GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs6951245 | 1 | rs74887741 | chr7:1110658 | ZFAND2A | chr7:1192544-1199855:- | -0.38 | -4.47 | 1.05E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs56322409 | 1 | rs749050 | chr10:97376115 | ENTPD1 | chr10:97471536-97637022:+ | 0.19 | 4.93 | 1.21E-6 | Blood metabolite levels |
| BLCA | cis | rs11723261 | 1 | rs74984113 | chr4:250522 | ZNF718 | chr4:53272-156488:+ | 0.34 | 4.55 | 7.25E-6 | Immune response to smallpox vaccine (IL-6) |
| BLCA | cis | rs6951245 | 1 | rs75016635 | chr7:1094121 | ZFAND2A | chr7:1192544-1199855:- | -0.37 | -4.41 | 1.32E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs9894429 | 1 | rs7503679 | chr17:79583843 | TSPAN10 | chr17:79609349-79615778:+ | 0.49 | 8.84 | 3.52E-17 | Eye color traits |
| BLCA | cis | rs7714584 | 1 | rs75071288 | chr5:150224379 | LOC134466 | chr5:150310000-150326146:- | 0.43 | 5.33 | 1.71E-7 | Crohn's disease |
| BLCA | cis | rs8133949 | 1 | rs75128809 | chr21:43418210 | C21orf121 | chr21:43442113-43445060:+ | 0.32 | 4.5 | 9.03E-6 | Hand grip strength |
| BLCA | cis | rs2275426 | 1 | rs7515491 | chr1:46355079 | CCDC163P | chr1:45960581-45965646:- | -0.36 | -6.71 | 6.87E-11 | Body mass index |
| BLCA | cis | rs12045807 | 1 | rs7517 | chr1:150596411 | HORMAD1 | chr1:150670542-150693352:- | 0.4 | 3.97 | 8.53E-5 | Congenital left-sided heart lesions |
| BLCA | cis | rs7589728 | 1 | rs75181745 | chr2:88520408 | THNSL2 | chr2:88469835-88486145:+ | -0.58 | -5.75 | 1.87E-8 | Plasma clusterin levels |
| BLCA | cis | rs751984 | 1 | rs751984 | chr11:61278246 | CD6 | chr11:60739115-60787846:+ | 0.22 | 4.4 | 1.4E-5 | Mean arterial pressure |
| BLCA | cis | rs12045807 | 1 | rs7520516 | chr1:150659695 | HORMAD1 | chr1:150670542-150693352:- | 0.38 | 3.91 | 0.00011 | Congenital left-sided heart lesions |
| BLCA | cis | rs2275426 | 1 | rs7522601 | chr1:46419021 | CCDC163P | chr1:45960581-45965646:- | -0.34 | -6.43 | 3.87E-10 | Body mass index |
| BLCA | cis | rs4660306 | 1 | rs7522705 | chr1:45992300 | CCDC163P | chr1:45960581-45965646:- | 0.68 | 13.43 | 5.59E-34 | Homocysteine levels |
| BLCA | cis | rs6684514 | 1 | rs7522948 | chr1:156275308 | BGLAP | chr1:156182784-156213112:+ | 0.25 | 4.08 | 5.59E-5 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |